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Development of an immunoassay for clenbuterol (CLB) detection required an anti-CLB antibody as an important bioreceptor. In this study, we report our work on production and purification of a rabbit-derived polyclonal anti-CLB antibody. Clenbuterol-treated hearts had normal expression of SERCA2a while thyroxine-treatment led to a 50% increase in SERCA2a expression (P = 0. There were no significant changes in SERCA2a expression in the isoproterenol group, although 2 of 5 hearts expressed only 50% of the mean control level. The clenbuterol imprinting was adequately demonstrated to not only increase the particle size (~52 nm vs. Current research Outlook Clenbuterol has approval for human use as an asthma drug in some countries but is banned for this use in the United States. Its side effects include anxiety, shaking,. 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